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Phenergan (promethazine) is an antihistamine that relieves nasal stuffiness and inflammation and red, inflamed eyes caused by hay fever and other allergies. It is also used to treat itching, swelling, and redness from hives and other rashes; allergic reactions to blood transfusions; and, with other medications, anaphylactic shock (severe allergic reaction).

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Uses

Relieving allergy symptoms, including hives and nasal congestion. It is used to prevent and control pain and nausea during and after surgery. It is also used to help produce light sleep, and for the prevention of motion sickness. Promethazine is not to be used to treat asthma. It may also be used for other conditions as determined by your doctor.
Promethazine is a phenothiazine antihistamine. It works by blocking the sites where histamine acts.

How to take

·1 Take promethazine by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
·2 If you are using promethazine for motion sickness, take a dose at least 30 to 60 minutes before you begin traveling.

Side effects

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Dizziness; drowsiness; dry mouth; increased or decreased blood pressure; nausea; occasional blurred vision; rash; sleepiness; vomiting.
Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); sensitivity to light; uncontrolled muscle movements; yellowing of skin or eyes.

Precaution

If you are taking other medications that cause sedation, your doctor may reduce the dosage of these medications or eliminate them while you are using promethazine.
If you have a seizure disorder, promethazine may cause your seizures to occur more often.
Promethazine can cause a serious--even fatal--decline in the breathing function. Avoid promethazine if you have chronic breathing problems such as emphysema or if you suffer from sleep apnea (periods during sleep when breathing stops).
Promethazine can also cause a potentially fatal condition called Neuroleptic Malignant Syndrome. Symptoms include high fever, rigid muscles, sweating, and a rapid or irregular heartbeat. If you develop these symptoms, stop taking promethazine and see your doctor immediately.
Use promethazine cautiously if you have heart disease, high blood pressure or circulatory problems, liver problems, the eye condition called narrow-angle glaucoma, peptic ulcer or other abdominal obstructions, or urinary bladder obstruction due to an enlarged prostate.
Promethazine may affect the results of pregnancy tests and can raise your blood sugar.
Some people have developed jaundice (yellow eyes and skin) while on promethazine.
Tell your doctor if you have any uncontrolled movements or seem to be unusually sensitive to sunlight.
Remember that promethazine can cause drowsiness.
Promethazine should not be given to children under 2 years of age, and should be used with caution in older children, due to the danger of impaired breathing. Large doses have been known to cause hallucinations, seizures, and sudden death, especially in children who are dehydrated. Drugs such as promethazine are not recommended for the treatment of vomiting in children unless the problem is severe. Promethazine should also be avoided if the child has the serious neurological disease known as Reye's syndrome or any disease of the liver.

Drug interactions

Promethazine may increase the effects of alcohol. Do not drink alcohol, or at least substantially reduce the amount you drink, while taking promethazine.
If promethazine is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining promethazine with the following:

Certain antidepressant drugs, including Elavil and Tofranil
Drugs that control spasms, such as Cogentin
Drugs that reduce bone-marrow function (certain cancer drugs)
MAO inhibitors such as the antidepressants Nardil and Parnate
Narcotic pain relievers such as Demerol and Dilaudid
Sedatives such as Halcion, Dalmane, and Seconal
Tranquilizers such as Xanax and Valium

Missed dose

If you miss a dose, take as soon as remembered; do not take if it is almost time for the next dose, instead, skip the missed dose and resume your usual dosing schedule. Do not "double-up" the dose to catch up.

Storage

Tablets should be stored between 2° (36°F) and 30°C (86°F).Keep away from children and pets.