Danazol or Danocrine.
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Danazol (Danocrine) slows production of the female hormone estrogen. Danocrine is a man-made steroid that has similar actions to androgens, or male sex hormones.

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Uses

Danocrine is a synthetic hormone. It is used to treat pain and infertility caused by endometriosis, a condition involving the tissue of the uterus. It is also used in the treatment of cysts or lumps in the breast or may be prescribed for heavy menstrual flow. Danocrine is also used to prevent attacks of angioedema in both males and females.

How to take

Take Danocrine capsules by mouth. Swallow the capsules with water. Take your doses at regular intervals.
Do not take your medicine more often than directed.

Side effects

May cause dizziness, headache, fatigue, appetite changes, stomach upset, bloating, or anxiety. These effects should disappear as your body adjusts to the medication. Other side effects include oily skin, weight gain, flushing, changes in sleep patterns, change in sex drive, mood changes, vaginal dryness or irritation, muscle cramps, chills, fluid retention in the hands or feet or nasal congestion. Notify your doctor if any of these become bothersome. Notify your doctor as soon as possible if you experience: depression, hot flashes, changes in ovulation, unusual swelling of feet or ankles; deepening of the voice, dark yellow or brown urine; decrease in breast size, difficulty passing urine or blood in the urine; nausea, vomiting, abnormal growth of fine body hair or facial hair; redness, blistering, peeling or loosening of the skin, including inside the mouth; skin rash or itching; stomach pain, unusual bleeding or bruising; vision changes, yellowing of the eyes or skin; one-sided weakness, slurred speech. Women often experience no or irregular menstrual periods while taking this medication. If you notice other effects not listed above, contact your doctor or pharmacist.

Precaution

Before you take Danocrine, tell your doctor if you have: breast cancer, heart disease, kidney disease, liver disease, migraine, porphyria, seizures (convulsions), unusual vaginal bleeding, strokes, prostate cancer, an unusual or allergic reaction to Danocrine, other medicines, foods, dyes, or preservatives; pregnant or trying to get pregnant; breast-feeding.
If dizziness or blurred vision occurs, use caution engaging in activities requiring alertness. Geriatric men are at increased risk of developing enlarged prostate and prostate cancer with the use of androgen-like drugs. Use of non-hormonal contraceptives such as a condom, diaphragm or sponge is recommended while taking this drug and until you have had at least one menstrual period after stopping the drug. Danocrine can cause menstrual periods to stop entirely but they usually resume within two to three months after Danocrine treatment. This drug must not be used during pregnancy. If you become pregnant or think you may be pregnant, inform your doctor immediately. Breast feeding should be avoided while using this drug.

Drug interactions

Before taking Danocrine, tell your doctor if you are using any of the following drugs: agents that dissolve blood clots,
aspirin or aspirin-like medicines, 'blood thinners' such as warfarin or heparin, carbamazepine, clopidogrel, cyclosporine,
doxercalciferol, medicines for high cholesterol (examples: lovastatin, simvastatin); medicines for diabetes, paricalcitol, red yeast rice,
sirolimus, tacrolimus, ticlopidine.
Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines. Do not take birth control pills while you are taking Danocrine.

Missed dose

If you miss a dose, take as soon as remembered; do not take if it is almost time for the next dose, instead, skip the missed dose and resume your usual dosing schedule. Do not "double-up" the dose to catch up.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F).

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